This analysis unveiled the following top 10 mutant genes in HNSCC patients, with their respective mutation frequencies indicated in parentheses: TP53 (69%), TTN (37%), FAT1 (21%), CDKN2A (20%), CSMD3 (18%), MUC16 (17%), NOTCH1 (17%), PIK3CA (17%), SYNE1 (16%), and LRP1B (15%) (Figure1A). Here, CSMD3 is linked to head and neck squamous cell carcinoma.