This overexpression did not rescue mutant FAT1 KO‐mediated decrease in CPT1A expression (Figure 2O) and accumulated LD formation (Figure 2P,Q), supporting the notion that mutant FAT1, but not wild‐type FAT1, promotes FAO by upregulating CPT1A in HNSCC cells. This evidence concerns the gene CPT1A and head and neck squamous cell carcinoma.