[34, 35, 36] We and other groups have demonstrated that wild‐type FAT1 serves as a tumor suppressor gene in HNSCC.[10, 11] The FAT1 gene is one of the most frequently mutated genes across various cancers, with a particularly high prevalence in HNSCC.[37] However, the functions of mutant FAT1 remain to be elucidated. The gene discussed is FAT1; the disease is head and neck squamous cell carcinoma.