SPDEF and pancreatic intraductal papillary-mucinous neoplasm: A recent study identified markers of gastric spasmolytic polypeptide–expressing metaplasia (SPEM) in human IPMN, with SAM pointed domain–containing Ets transcription factor (SPDEF), CREB3L1, and CREB3L4 emerging as key transcriptional regulators of this phenotype (bioRxiv 2024.02.25.581948).