As a central regulator of intracellular redox homeostasis (18), NRF2 mitigates oxidative stress, raising the question of whether reactive oxygen species (ROS) influence the distinct progression of KRASG12D-mutant pancreatic epithelial cells into PanIN or IPMN lesions. This evidence concerns the gene NFE2L2 and pancreatic intraductal papillary-mucinous neoplasm.