The expression of total, nuclear, and phosphorylated NRF2 did not correlate with the histologic grade of the IPMN lesions (Fig. 1F; Supplementary Fig. S1A–S1C) or the mutational status of GNAS (R201C), the most frequently observed genetic alteration in IPMN (Fig. 1F; Supplementary Fig. S1D–S1F; ref. 28). This evidence concerns the gene GNAS and pancreatic intraductal papillary-mucinous neoplasm.