Using a pancreas-specific NRF2 knockout model (Nfe2l2flox/flox;Pdx1-Cre), we observed a significant increase in IPMN-like cystic tumor formation in KRASG12D-mutant pancreatic epithelium, implicating NRF2 as a suppressor of IPMN. The gene discussed is NFE2L2; the disease is cystic neoplasm.