The majority of E2Fs present active transcription functions in the tumor process.19 As an exception, E2F7 is classified as the sporadic atypical member depending on the different regulating mechanisms and the inverted repressive regulation of the genes for cell proliferation.20 Here, we found that highly expressed E2F7 in HCC cells was correlated with the decline of the transcription of both MT2P1 and its parental gene MT2A. Here, E2F7 is linked to hepatocellular carcinoma.