Additionally, mutations in key ALS‐related genes, including TAR DNA binding‐protein 43 (TDP‐43), fused in sarcoma (FUS), superoxide dismutase 1 (SOD1), and the C9orf72 repeat expansion, have been associated with impaired mitochondrial function and Ca2+ regulation [154]. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.