Recent studies also suggested that the Sig‐1R–AAA ATPase domain‐containing protein 3A (ATAD3A) axis and MAM‐TANK‐binding kinase 1 (TBK1) axis could be a promising new therapeutic point for mitochondrial dysfunction in neurological disorders including ALS [176, 177]. Here, SGCG is linked to amyotrophic lateral sclerosis.