In a clinical study comparing Japanese individuals having fulminant type 1 diabetes to healthy controls regarding the HLA-DRB1 and HLA-DRQ1 genes, which are associated with susceptibility to type 1 diabetes, those with fulminant type 1 diabetes had DRB1*04:05-DQB1*04:01 and DRB1*09:01-DQB1*03:03 with significantly higher frequency and DRB1*01:01-DQB1*05:01, DRB1*15:02-DQB1*06:01, and DRB1*08:03-DQB1*06:01 with significantly lower frequency than those without diabetes [7]. The gene discussed is HLA-DRB1; the disease is diabetes mellitus.