PIK3CA and cancer: NGS of 49 key cancer-related genes (AKT1, ALK, APC, ARAF, BRAF, CDKN2A, CTNNB1, CYSLTR2, DDR2, EGFR, EIF1AX, ERBB2, ERBB4, ESR1, FBXW7, FGFR1, FGFR2, FGFR3, GNA11, GNAQ, GNAS, H3F3A, HIST1H3B, HRAS, IDH1, IDH2, KEAP1, KIT, KRAS, MAP2K1, MET, NOTCH1, NRAS, NTRK1, PDGFRA, PIK3CA, PLCB4, POLD1, POLE, PTEN, RAC1, RAF1, RET, RNF43, ROS1, SMAD4, STK11, TERT, TP53) was only remarkable for a variant of uncertain significance (VUS) of PIK3CA (P377R).