In addition to prognostic value for incident dementia,5, 6, 7, 8, 9, 10 MBI is associated with AD neuropathologic changes, including cerebrospinal fluid (CSF) Aβ42/Aβ40 ratio11 and p‐tau181,11, 12, 13 Aβ14 and tau positron emission tomography (PET)12, 15 imaging markers, and neurodegeneration.16, 17. The gene discussed is MAPT; the disease is dementia.