The cytokine-cytokine receptor pathway featured 35 genes (p = 3.79 × 10−7), such as CCL5, CXCL10, and IFNG, indicating impaired chemokine-mediated immune cell recruitment (e.g., CD8+ T cells and macrophages) in the immunosuppressive glioma microenvironment (28). This evidence concerns the gene CCL5 and central nervous system cancer.