Given the observed variability in IBS symptoms, as assessed by the GSRS, in the subgroup of patients with IBS-D, we looked into associated factors using a bivariate regression model, including sex, age at diagnosis, history of atopy, allergic comorbidities (including atopic dermatitis), total IgE levels, and specific IgE levels for grass as covariates. Here, IGHE is linked to atopic eczema.