Further experimental in vitro confirmation of the importance of the regulation of MDM2/p53 axis came from the work of Guo who stated that miR-26a can act as a tumor suppressor miRNA and regulate this signaling pathway decreasing MDM2 and increasing p53 expression levels, which resulted in reduced viability of UM cells (Guo and Tian, 2020). This evidence concerns the gene TP53 and neoplasm.