MYH6 and cardiac hypertrophy: Additionally, MYH6 mutations can lead to a spectrum of dilated and hypertrophic phenotypic changes, ranging from DCM to HCM, including myocardial hypertrophy progressing to dilation and systolic dysfunction (Carniel et al., 2005), as well as severe adverse outcomes in DCM patients, such as sudden death and heart failure (Merlo et al., 2013).