The role of HMGN2 in HF has not been fully elucidated, but studies suggest that endogenous HMGN2 acts as a positive regulator of NF-κB signaling and modulates intracellular ROS homeostasis through the Nrf2 pathway, thereby regulating oxidative stress and actin cytoskeleton rearrangement (Liu et al., 2017). The gene discussed is HMGN2; the disease is hydrops fetalis.