The role of HMGN2 in HF has not been fully elucidated, but studies suggest that endogenous HMGN2 acts as a positive regulator of NF-κB signaling and modulates intracellular ROS homeostasis through the Nrf2 pathway, thereby regulating oxidative stress and actin cytoskeleton rearrangement (Liu et al., 2017). This evidence concerns the gene NFKB1 and hydrops fetalis.