Although the mutation in NRAMP-1 does not influence Mtb infection, it has been shown that polymorphism in the human ortholog of NRAMP-1 play a role in human TB susceptibility in certain populations (Bellamy et al., 1998; Cervino et al., 2000; Gao et al., 2000; Ryu et al., 2000). Here, SLC11A1 is linked to tuberculosis.