These findings suggest that hyperglycemia can exacerbate the inflammatory response of gingival tissue through the NLRP3 pathway, contributing to greater tissue degradation (Huang et al., 2015), because high levels of IL-1β were significantly associated with periodontitis immunopathology, causing periodontal tissue degradation, mainly in alveolar bone absorption and damage to the lamina propria (Figure 1) (Liu et al., 1996). The gene discussed is NLRP3; the disease is periodontitis.