(2015) reported that, both in patients with chronic periodontitis and T2DM, as well as human gingival epithelial cells (HGEC) stimulated with lipopolysaccharide (LPS) and high concentrations of glucose, showed a significant increase in the expression of the NLRP3 inflammasome and IL-1β. Here, NLRP3 is linked to type 2 diabetes mellitus.