IL6 and Insulin resistance: This state favors the overproduction of proinflammatory cytokines and adipokines, including tumor necrosis factor alpha (TNF)-α, interleukin (IL)-6, leptin, and resistin, which not only exacerbate insulin resistance but also contribute to the establishment of a chronic low-grade inflammatory microenvironment (Gerrits et al., 2012; Villarreal-Pérez et al., 2014; Sun et al., 2018).