INS and type 2 diabetes mellitus: T2DM is characterized by presenting various defects at a biochemical and pathophysiological level, which are associated with peripheral insulin resistance, increased hepatic glucose production, altered levels of intestinal hormones that regulate insulin and glucagon function, decrease and failure of pancreatic β cells function, as well as additional mechanisms that are related to inflammation (Defronzo, 2009; Brunton, 2016; Javeed and Matveyenko, 2018).