By leveraging Machine Learning and Support Vector Machine (SVM) method, we ultimately identified four intersecting proteins (albumin [ALB, Swissprot: A0A0C4DGB6], haptoglobin [HP, Swissprot: P00738], Out at first protein homolog [OAF, Swissprot: E9PJ29], and retinol-binding protein 4 [RBP4, Swissprot: P02753]) as promising biomarkers for assessing the efficacy of pulmonary tuberculosis treatment. Here, OAF is linked to pulmonary tuberculosis.