Emerging evidence underscores the pivotal role of the cGAS-STING pathway in the pathogenesis of various inflammatory lung diseases, spanning cystic fibrosis (CF) (Benmerzoug et al., 2018), chronic obstructive pulmonary disease (COPD) (Nascimento et al., 2019), idiopathic pulmonary fibrosis (IPF) (Schuliga et al., 2020), asthma (Han et al., 2020), COVID-19 (Domizio et al., 2022), and acute respiratory distress syndrome (ARDS) (Zhao et al., 2023). The gene discussed is CGAS; the disease is COVID-19.