Key DEPs, including Cgas, Sting (Tmem173, Sting1), Ifnb1, Nlrp3, Asc (Pycard), Gsdmd, Caspase 1, and Caspase 3, were markedly elevated in ARDS lungs versus controls, as illustrated in the volcano plot and heatmap in Figures 1B,C. The gene discussed is PYCARD; the disease is acute respiratory distress syndrome.