In addition to mechanism exploration, anti-hepatic fibrosis therapeutic strategies targeting macrophages have also been a hot research topic, and the discovery of CC chemokine ligand 2 (CCL2) antagonists (Baeck et al., 2012) and bone marrow-derived macrophages (Thomas et al., 2011) have attracted extensive attention in the field. This evidence concerns the gene CCL2 and Hepatic fibrosis.