Elevated expression of CCAAT/enhancer-binding protein beta (CEBPB) accelerates the malignant progression of colorectal cancer (CRC) by activating the PI3K/AKT/mTOR signaling pathway and decreasing CRC cell sensitivity to cuproptosis in a CRC cuproptosis model (Huang T. et al., 2024). The gene discussed is CEBPB; the disease is colorectal cancer.