FOXO3 and nonpapillary renal cell carcinoma: Conversely, the upregulation of adrenomedullin (ADM) was found to inhibit FDX1 expression and mediate sunitinib resistance in ccRCC by facilitating FOXO3 phosphorylation and its nuclear translocation (Wei et al., 2024; Lin Z. et al., 2020; Bing et al., 2021; Wang et al., 2023c).