As used in our previous study, six-week-old nude mice injected the CRC cell line HCT116 with ectopic ITGBL1 expression into nude mice and reported a 100% incidence rate of lung metastasis in these xenograft mice (Ji et al., 2020), indicating that MiR-200c/MDR1 can promote the invasion and migration of CRC cells. Here, ITGBL1 is linked to colorectal carcinoma.