In mechanism level, LPS produced by gram-negative bacteria might lead to metabolic endotoxemia and LPS -dependent production of inflammatory cytokines, such as Interleukin-6 and Tumour Necrosis Factor-α that can contribute to development of insulin resistance and T2DM (Duan et al., 2018; Schwartz et al., 2016). This evidence concerns the gene IL6 and Insulin resistance.