After recognizing tumor antigens, CAR T cells are activated and secrete large amounts of perforin, granzyme, and inflammatory cytokines such as IFN-γ, tumor necrosis factor-α (TNF-α), IL-2, IL-6, etc., to induce pyroptosis of tumor cells and release a large number of damage-associated molecular patterns (DAMPs) (Giavridis et al., 2018; Shimabukuro-Vornhagen et al., 2018). This evidence concerns the gene PRF1 and neoplasm.