ITGA4 and B-cell chronic lymphocytic leukemia: In details, relapse/refractoriness in the entire CLL cohort was associated with age at diagnosis (p = 0.0041), grade of lymphocytosis (p = 0.003), and platelet count (p = 0.0073), while negativity for CD38 and CD49d markers had a protective effect on PFS (p = 0.0373).