CD38 and B-cell chronic lymphocytic leukemia: In this single-center retrospective study, we described CD38 prognostic role in CLL patients treated with standard chemotherapies or anti-CLL agents, with various therapeutic sequencing approaches in a real-life setting over a ten-year follow-up period at Hematology and Transplant Center, University Hospital “San Giovanni di Dio e Ruggi D’Aragona”, Salerno, Italy.