The HAVCR1 gene encodes a type I transmembrane glycoprotein (43), which is upregulated in various cancers, including esophageal cancer, lung adenocarcinoma, and gastric adenocarcinoma with different pathological characteristics, and its expression is associated with poor prognosis in these cancers (42, 44, 45). The gene discussed is HAVCR1; the disease is cancer.