To investigate the prognostic significance of 12 key genes (EFNA1, CXCL8, EZH2, PAQR4, SLC27A6, SPINK5, SYCP2, YEATS2, F10, PPP1R14A, FBLN5, ABCA8) in CESC, we conducted a comprehensive survival analysis. The gene discussed is SPINK5; the disease is cervical squamous cell carcinoma.