To confirm that upregulation of the P4HA2 gene plays an important role in the development of colorectal cancer, the authors examined the expression of P4HA2 in the human normal intestinal epithelial cell line HIEC and the colorectal cancer cell lines LoVo, SW480, SW620, HT29, and HCT8. Here, P4HA2 is linked to colorectal cancer.