To determine the involvement of P4HA2-regulated STAT1 in CRC tumorigenesis, HCT8 cells were divided into four groups for in vitro experiments: the control shRNA + si-NC, control shRNA + si-STAT1, P4HA2 shRNA + si-NC, and P4HA2 shRNA + si-STAT1 groups. This evidence concerns the gene P4HA2 and colorectal carcinoma.