(20) indicated that AFP, CEA, CA199, CA125, and CA724 were commonly used clinical serum tumor markers, which played a crucial role in the diagnosis, prognosis, and recurrence monitoring of gastrointestinal malignancies, and that they identified CA125 as an independent prognostic risk factor for gastric cancer patients through ROC curve plotting and Cox regression analysis. The gene discussed is AFP; the disease is neoplasm.