In univariable GEE analysis (77 participants, 246 visits), upper tertiles (T3 vs. T1-2) of ALT and GGT (OR 2.09, 95% CI [1.23, 3.57] and 3.08 [1.66,5.73], respectively) predicted incident CAN. The gene discussed is GPT; the disease is Crouzon syndrome-acanthosis nigricans syndrome.