Adolescents with CAN and overweight/obesity (BMI > 85th centile) had higher ALT (21.3 IU/L vs. 14.5 IU/L p=0.03) and AST (26.5 IU/L vs. 22.2 IU/L, p=0.004) compared to adolescents without CAN and higher BMI. The gene discussed is GPT; the disease is obesity due to melanocortin 4 receptor deficiency.