The estimated mean weight-adjusted insulin requirement was higher in patients with diabetes onset during the COVID-19 pandemic compared to those with diabetes onset before the pandemic at 3–5 months (mean estimated difference, 0.06 U/kg [95% CI 0.04; 0.07], p  < 0.001), at 6–10 months (mean estimated difference, 0.05 U/kg [0.03; 0.06], p  < 0.001), and at 11–13 months (mean estimated difference, 0.03U/kg [0.01; 0.05], p  < 0.001) after type 1 diabetes diagnosis (Figure 2). Here, INS is linked to diabetes mellitus.