Of note, a prior study from our group of 8–10-month-old APP/PS1 mice (another model of amyloidosis) demonstrated intact vasomotion with impaired vascular reactivity in response to visual stimuli.9 Future studies are needed to determine whether and when sensory stimulus-evoked vascular reactivity is affected in APP23 mice; it is possible that pathways dependent on neurovascular coupling are more profoundly affected by vascular (and parenchymal) amyloid-β accumulation. Here, APP is linked to amyloidosis.