MDM4 and neoplasm: In previous studies, up-regulation of NR3C1 was associated with enhanced cell proliferation and migration, possibly through metabolic regulation and signaling pathway interactions.NR3C1 and its related regulators (e.g., MDM4, SETBP1, and NF-κB) were potential therapeutic targets, and tumor progression could be inhibited and treatment enhanced by modulating NR3C1 expression (83, 84).