C3 IGHG4+ myeloma cells were enriched in cytoplasmic translation, ribosome biogenesis, ribonucleoprotein complex biogenesis, ribosomal small subunit biogenesis, rRNA processing, ribosome assembly, and other pathways (Figure 3N).Taken together, it suggests that cellular proliferation is more active in C0 IGLC3+ Myeloma cells and was associated with oxidative phosphorylation, which might regulate metabolic activities through a specific pathway and therefore had a significant impact on the growth and metastasis of MM tumors. The gene discussed is IGLC3; the disease is plasma cell myeloma.