The results showed that KLF6, NR3C1, IRF7 and YY1 were all actively regulated in C0 IGLC3+ Myeloma Cells, C1 IGHA1+ Myeloma Cells, and JUN was actively regulated in C0 IGLC3+Myeloma Cells, C1 IGHA1+ Myeloma Cells and C3 IGHG4+ Myeloma Cells. This evidence concerns the gene KLF6 and plasma cell myeloma.