The regulatory activities of the four myeloma cell subpopulations varied in different regulatory modules (Figures 5E, F), with some degree of regulatory activity of C0 IGLC3+ Myeloma cells in the M1 and M4 regulatory modules, C0 IGLC3+ Myeloma cells and C1 IGHA1+ Myeloma cells in the M2 regulatory module. This evidence concerns the gene IGHA1 and plasma cell myeloma.