The specific receptor-ligand pairs such as CX3CL1-CX3CR1, NGF-NTRK1, APP-CD74, and MIF-CD74 highlight key signaling axes that influence the communication network in the myeloma microenvironment, suggesting potential therapeutic targets for disrupting these pathways and improving treatment outcomes in multiple myeloma. Here, CX3CR1 is linked to plasma cell myeloma.