FAP and cancer: Indeed, our constructed OHSV2-DSTEFAP/CD3 expressing DSTEs and an adenovirus ICO15K-FBiTE targeting FAP on CAFs both can exert superimposed effects through simultaneously inducing cancer cell lysis by OVs and fostering immune synapse-mediated depletion of FAP+ CAFs by CD3+ T cells (40, 42), thus outperforming their parental virus alone.