The levels of neopterin (F = 0.54, p = .91), IL-6 (F = 0.96, p = .45), ORM-2 (F = 0.83, p = .43), perceived pain (F = 2.69, p = .10), perceived RA disease activity (F = 0.50, p = .71), mood (F = 2.12, p = .12), mental activity (F = 0.60, p = .85) and body temperature (F = 0.50, p = .71) did not differ before and after the medication change. The gene discussed is IL6; the disease is rheumatoid arthritis.