Interactions between follicular helper T cells (CD4 TFH), tissue-resident T cells (CD8 TRM), and B cells mediated by the CXCL13–CXCR5 axis are crucial for anti-tumor immunity in EGFR-mutated non-small cell lung cancer (NSCLC). The gene discussed is CXCL13; the disease is non-small cell lung carcinoma.