The oligopeptide has a higher affinity with the MD2 portion of the TLR4/MD2 complex (KD=2.97×10–8 M) than eCIRP and can reduce inflammation and injury in mice subjected to sepsis, hemorrhagic shock, mesenteric I/R, or pancreatitis (103, 110, 111, 138). This evidence concerns the gene LY96 and Sepsis.