Extracellular Cu2+ can form complexes with specific ionophores, which facilitate its passage through the cytoplasm and into the mitochondria, where it is converted into toxic compounds under the key regulation of ferredoxin 1 (FDX1) and strong Cu1+ (43–45).Currently, there are no relevant studies examining the relationship between copper wire mesh and liver fibrosis. Here, FDX1 is linked to Hepatic fibrosis.