Also, the CSRGs risk score is significantly related to many cancer-associated pathways (Figures 5B, C), including ECM receptor interaction, focal adhesion (NES = 2.395), TGF-β signaling pathway (NES = 1.966), WNT signaling pathway (NES = 1.792), pathway in cancer (NES = 1.779), and primary immunodeficiency (NES = -1.881). This evidence concerns the gene TGFB1 and inborn error of immunity.