For B cells of JIA and cHC, three subtypes had been identified by evaluating the expression of CD38, MZB1, XBP1, TNFRSF13B, CD79A, CD79B, CD19, MS4A1, IGHD, TCL1A (Figures 1D, E), these included Naïve B (Naïve B cells), Memory B (Memory B cells) and Plasma B (Plasma B cells) (Figures 1D, E). The gene discussed is MZB1; the disease is juvenile idiopathic arthritis.