Further investigation of gene expression and functionality of CCR7+/RELB+/IRF1+ triple positive T cells in JIA versus other CCR7+ T cells revealed significantly enriched upregulated DEGs associated with cytokine production (GO:0001816), TNF signaling pathway (KEGG:04668), and IL-17 signaling pathway (KEGG:04657) and non-canonical NF-kappaB signal transduction (GO:0038061) (Figure 2I). This evidence concerns the gene IRF1 and juvenile idiopathic arthritis.