Specifically, the upregulated DEGs in CD14 Mono and CD16 Mono from both HLA-B27- JIA and HLA-B27+ JIA demonstrated significant enrichment in immune-related GO terms, including immune system processes (GO:0002376), immune response (GO:0006955), and MAPK cascade (GO:0007255) (Figure 6D). The gene discussed is FCGR3A; the disease is juvenile idiopathic arthritis.