Further GO enrichment analysis revealed that DEGs co-upregulated by CD14 Mono in both HLA-B27- JIA and HLA-B27+ JIA (n=133, 30.2%) were notably enriched in IL-1 beta production (GO:0050720), IL-6 production (GO:0042226), and IL-8 production (GO:0042228). Here, CXCL8 is linked to juvenile idiopathic arthritis.