Notably, HLA-B27- JIA demonstrated a higher number of upregulated DEGs associated with IL-6 production (GO:0042226) and IL-8 production (GO:0042228), indicating a potentially heightened capacity for pro-inflammatory interleukin production in CD14 Mono from HLA-B27- JIA (Figures 6E, F). The gene discussed is CXCL8; the disease is juvenile idiopathic arthritis.