In the therapeutic context of experimental RA, paeonol is utilized mainly for its anti-inflammatory function, alleviating some phenotypes of joint inflammation, diminishing the conduction and expression of relevant inflammatory signaling pathways (TLR4/NF-κB, PI3K/AKT/NF-κB) and downregulating the levels of inflammation-related mediators (Table 1, Figure 2). This evidence concerns the gene TLR4 and rheumatoid arthritis.