Icariin also further ameliorated the inflammatory activation and hyperproliferative state of TNF-α-stimulated RA- FLS, which may be achieved by specifically upregulating the expression of Nrf2 and TRIB1 to suppress the over-activation of TLR2/NF-κB signaling pathway or by modulating the miR-223-3p/NLRP3 axis (86, 87). This evidence concerns the gene TNF and rheumatoid arthritis.