The tumor-suppressive microenvironment is influenced by various inhibitory immune cells, including myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), regulatory T cells (Tregs), tumor-associated neutrophils (TANs), and cancer-associated fibroblasts (CAFs), along with inhibitory cytokines like IL-6, IL-8, and TGF-β. This evidence concerns the gene TGFB1 and neoplasm.