The duplication in the 9p region involves the NFIB gene, the abnormality of which has been confirmed to be associated with acquired megalencephaly with intellectual disability, mainly characterized by intellectual disability, hypotonia, and seizures (Schanze et al., 2018; Barrus et al., 2020; Rao and Goel, 2020). This evidence concerns the gene NFIB and Intellectual disability.