In addition, shRNA targeting SOD1 to be transported by AAV9 vector (AAV9-SOD1-shRNA) and CRISPR-Cas9 targeting SOD1 to be transported by AAV9 can reduce mutant SOD1 protein, thus improving motor function and prolonging survival in mouse models of ALS (Foust et al., 2013; Gaj et al., 2017). Here, SOD1 is linked to amyotrophic lateral sclerosis.