Low-density lipoprotein receptor-related protein 1 (LRP1) is a receptor for amyloid-β on endothelial cells, and when LRP1 binds amyloid-β, it transports amyloid-β to lysosomes for degradation, with expression levels inversely correlating with the development of AD (Herz et al., 1988). Here, LRP1 is linked to Alzheimer disease.