Increased BST2 expression has been observed in multiple human cancers, including hematological tumors and solid tumors, especially in breast cancer, HCC, gastrointestinal cancer, and lung cancer (28) via activating signaling pathways, such as EGFR/AKT, NF-κB/ERK, and GRB2/DIM/caspase 3 (29–31). This evidence concerns the gene GRB2 and lung cancer.