NRP1 and neoplasm: It is characterized as a single-pass transmembrane receptor comprising an extracellular domain, transmembrane and juxtamembrane regions, and a tyrosine kinase domain (16). In cancer, aberrant MET signaling contributes to tumor invasion and regulates various physiological processes, including embryogenesis, wound healing, liver regeneration, angiogenesis, and immunomodulation (17–20).