Similarly, in HCC, which accounts for 1 in 10 cancer-related deaths in men and 1 in 20 in women [26], the Wnt/β-catenin signalling pathway is altered in 54% of all cases, primarily through activating mutations in CTNNB1 (37%), encoding β-catenin and inactivating mutations in AXIN1 (11%) [32]. The gene discussed is AXIN1; the disease is hepatocellular carcinoma.