Increased LGR5 transcript levels have been reported for primary intestinal adenomas [11], gastric cancer [12], basal cell carcinoma [13], ovarian cancer [14], cervical cancer [15], glioblastoma [16], and precursor B-cell acute lymphoblastic leukaemia (pre-B ALL) [17, 18]. This evidence concerns the gene LGR5 and acute lymphoblastic leukemia.