- Ongoing active warming as required - Monitor for CAD with blood results and clinical symptoms and signs - Daily blood investigations: Fully blood count (FBC), Electrolytes, Urea, Creatinine (EUC), haptoglobin, lactose dehydrogenase, bilirubin - Inpatient haematology consultation and close outpatient follow-up. The gene discussed is HP; the disease is cold agglutinin disease.