IL1B and infectious otitis media: We also found that contrasted to the AOM/DSS group, the lesions and cancerization of the colon were alleviated memorably (Figures 9A,B, p < 0.001, p < 0.0001, p < 0.0001), pro-inflammatory factors like IL-1β, IL-6, and TNF-α were downregulated obviously (Figures 9C–E, p < 0.001 or p < 0.0001), and anti-inflammatory factor, like IL-10, was upregulated noticeably (Figure 9F, p < 0.001, p < 0.0001, p < 0.05) after intervention by HRCR-L, HRCR-M, and HRCR-H, respectively.