After HRCR-M treatment, the significant suppression of the expression levels of RAS, ERK, IKB, MEKK1, and NF-kB was identified in comparison to the AOM/DSS group (Figures 11B–F, p < 0.001, p < 0.05, p < 0.01, p < 0.0001, p < 0.001). The gene discussed is MAP3K1; the disease is infectious otitis media.