This contrasts with previous studies in 7-month-old ApoE−/− mice,101 12-month LDLR−/− mice fed a high cholesterol diet102,103 or 15 to 18 month APP mice fed an atherogenic diet,104 where anxiety behaviors were similar across all assessed groups, but the atherosclerosis mice showed significantly poorer performance on the Morris water maze task of spatial memory. Here, APOE is linked to atherosclerosis.