Neurovascular deficits have previously been reported in the LDLR−/− model of atherosclerosis, where Lu et al.,40 reported weaker evoked-hemodynamic responses to a whisker stimulation, as well as hypoxic pockets in cortical tissue and microvascular changes in capillaries in atherosclerotic mice at 12 months of age (versus atherosclerotic mice at 3 months where no lesions were yet present in the aorta, carotid arteries, or cerebral arteries). The gene discussed is LDLR; the disease is atherosclerosis.