Although it was surprising that we found no effects of AD or mixed AD and atherosclerotic disease on evoked-hemodynamic peak responses in this more “severe” APP/PS1 model of AD,50 previous investigations of hemodynamic responses in APP/PS1 mice, which have shown perturbations in stimulation-evoked hemodynamic responses had distinct methodological differences to this study. The gene discussed is APP; the disease is Alzheimer disease.