Many studies have shown that HULC functions in cancer by interacting with miRNA.[53, 54] Research has also indicated that broad H3K27me3 can identify oncogenes,[8] and HULC has been identified as an oncogene.[15] In a previous study, CURD reduced H3K27me3 and caused highly upregulated HULC in liver cells.[55]. The gene discussed is HULC; the disease is cancer.