XIST and cancer: XIST is a widely studied lncRNA that controls X chromosome inactivation (XCI) by recruiting multiple proteins, and a recent study showed that the modular secondary structure of XIST interacts with distinct sets of effector proteins.[48] Many studies have also shown that XIST plays a role in cancer development by interacting with miRNAs.[49, 50]NORAD is a critical lncRNA in human cancers, and its positions of SAM68‐binding sites motif secondary structure were more stable than other positions.[51] Meanwhile, POCALI identified “secondary structure MFE” as the most critical feature of NORAD.