One eHTA approach to examine the early diagnosis of rheumatoid arthritis (RA) was explored by Buisman et al. (61), who examined four potential diagnostic tests: B-cell RNA expression, IL-6 serum level test, MRI, and a genetic assay with susceptibility single nucleotide polymorphisms, all against the RA-2010 criteria. The gene discussed is IL6; the disease is rheumatoid arthritis.