To further explore the role of NRF2 in PIP5K1A‐induced growth and sorafenib resistance of HCC cells, we altered NRF2 expression by transfecting PIP5K1A‐overexpressing cells with NRF2‐siRNA and PIP5K1A‐knockdown cells with NRF2‐overexpression plasmid. Western blotting was used to confirm the transfection efficiency (Figure S7A,B, Supporting Information). Here, NFE2L2 is linked to hepatocellular carcinoma.