NFE2L2 and neoplasm: It is well established that NRF2 plays a vital role in protecting cells from oxidative stress.[24] The overactivation of NRF2 promotes tumor survival and drug resistance by upregulating the expression of its downstream genes, which are involved in antioxidation, cellular metabolism and iron homeostasis.[25] Since sorafenib has been identified as a potential inducer of ferroptosis, the role of NRF2 in sorafenib resistance has attracted considerable attention.