KRAS and familial pancreatic carcinoma: Numerous studies have reported that PIP5K1A is overexpressed in several malignant tumors and promotes the proliferation and migration of cancer cells.[17, 18, 19, 20, 21] Recent researches have also explored PIP5K1A's role in tumors independent of the PI3K/AKT pathway. For instance, PIP5K1A has been shown to interact with a unique region of KRAS, and its depletion significantly sensitizes pancreatic cancer cell lines to inhibitors of RAS effector pathways.[22] In addition, Choi et al.