Based on IHC scoring, HCC patients were stratified into the following four groups as indicated in Figure9A: group I (n = 170), low NRF2 and low PIP5K1A; group II (n = 34), high NRF2 and low PIP5K1A; group III (n = 97), low NRF2 and high PIP5K1A; and group IV (n = 53), high NRF2 and high PIP5K1A. Here, NFE2L2 is linked to hepatocellular carcinoma.