As a substrate for the production of phosphatidylinositol 3,4,5‐triphosphate (PIP3), PIP2 is essential for activating the PI3K/AKT pathway.[13] To the best of our knowledge, PIP5K1A has only been implicated in liver regeneration after liver injury,[14] its role in HCC remains largely unexplored. The gene discussed is AKT1; the disease is hepatocellular carcinoma.