This regulatory mechanism is analogous to PIP5K1A's interaction with let‐7 miRNA, in which PIP5K1A interacts with XPO5 to regulate mature miRNA levels by disrupting the binding of XPO5 to pre‐let‐7 miRNAs in a kinase‐independent manner.[38] Considering the importance of PIP5K1A and KEAP1/NRF2 signaling in HCC, further work is needed to fully elucidate the specific interaction sites between PIP5K1A and KEAP1. The gene discussed is NFE2L2; the disease is hepatocellular carcinoma.