However, in the infarction scar area, consisting mostly of fibrous tissue, the expression of Cdkn2a was increased in WT mice, yet both Cdkn2a and ‐b remained significantly lower in Chr4Δ70kb/Δ70kb mice, suggesting that Ak148321 may regulate the Cdkn2a/b expression. This evidence concerns the gene CDKN2A and infarction.