CDKN2B-AS1 and coronary artery disorder: Moreover, ANRIL has both linear (lin) and circular (circ) splicing isoforms, and several studies have demonstrated them having different effects, as the linear isoforms seem to be associated with an elevated risk for CVDs, while circANRIL has been associated with protection towards both CAD and MI (Burd et al., 2010; Holdt et al., 2016; Razeghian‐Jahromi et al., 2022; Rodríguez‐Esparragón et al., 2023).