Mechanistically, CRC cells release lactate to upregulate the expression of VSIG4 in macrophages through epigenetic modification, and VSIG4 promotes PPAR‐γ expression and FAO of macrophages by regulating the JAK2/STAT3 signalling pathway, thus promoting macrophages towards M2 polarization . The gene discussed is STAT3; the disease is colorectal carcinoma.