Given that M2 macrophages are known to induce epithelial‐mesenchymal transformation (EMT) in cancer cells, we explored the correlation between VSIG4 and several biomarkers associated with EMT processes (MMP9, SNAI1, SNAI2, VIM, TWIST1, TWIST2, CDH1, CDH2) in CRC through the TIMER2.0 website. This evidence concerns the gene TWIST2 and cancer.